CovidVariantV1, Main, Exploration, bibRecord, 000005

The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.

Identifieur interne : 000005 ( Main/Exploration ); précédent : 000004; suivant : 000006

The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.

Auteurs : Juan G Mez [Espagne] ; Guillermo M. Albaiceta [Espagne] ; Elías Cuesta-Llavona [Espagne] ; Marta García-Clemente [Espagne] ; Carlos L Pez-Larrea [Espagne] ; Laura Amado-Rodríguez [Espagne] ; Inés L Pez-Alonso [Espagne] ; Santiago Mel N [Espagne] ; Marta E. Alvarez-Argüelles [Espagne] ; Helena Gil-Pe A [Espagne] ; José R. Vidal-Casti Eira [Espagne] ; Viviana Corte-Iglesias [Espagne] ; María L. Saiz [Espagne] ; Victoria Alvarez [Espagne] ; Eliecer Coto [Espagne]

Source :

Cytokine [ 1096-0023 ] ; 2021.

RBID : pubmed:33113474

Descripteurs français

English descriptors

KwdEn :
- Aged (MeSH), Asian Continental Ancestry Group (genetics), COVID-19 (blood), COVID-19 (epidemiology), COVID-19 (genetics), European Continental Ancestry Group (genetics), Female (MeSH), Gene Frequency (MeSH), Genetic Predisposition to Disease (MeSH), Genotype (MeSH), Humans (MeSH), Linear Models (MeSH), Male (MeSH), Membrane Proteins (blood), Membrane Proteins (genetics), Middle Aged (MeSH), Polymorphism, Genetic (MeSH), RNA-Binding Proteins (blood), RNA-Binding Proteins (genetics), Risk Factors (MeSH).
MESH :
- chemical , blood : Membrane Proteins, RNA-Binding Proteins.
- blood : COVID-19.
- epidemiology : COVID-19.
- genetics : Asian Continental Ancestry Group, COVID-19, European Continental Ancestry Group, Membrane Proteins, RNA-Binding Proteins.
- Aged, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Linear Models, Male, Middle Aged, Polymorphism, Genetic, Risk Factors.

Abstract

BACKGROUND AND AIMS

The interferon-induced transmembrane proteins play an important antiviral role by preventing viruses from traversing the cellular lipid bilayer. IFITM3 gene variants have been associated with the clinical response to influenza and other viruses. Our aim was to determine whether the IFITM3 rs12252 polymorphism was associated with the risk of developing severe symptoms of COVID-19 in our population.

METHODS

A total of 288 COVID-19 patients who required hospitalization (81 in the intensive care unit) and 440 age matched controls were genotyped with a Taqman assay. Linear regression models were used to compare allele and genotype frequencies between the groups, correcting for age and sex.

RESULTS

Carriers of the minor allele frequency (rs12252 C) were significantly more frequent in the patients compared to controls after correcting by age and sex (p = 0.01, OR = 2.02, 95%CI = 1.19-3.42). This genotype was non-significantly more common among patients who required ICU.

CONCLUSIONS

The IFITM3 rs12252 C allele was a risk factor for COVID-19 hospitalization in our Caucasian population. The extent of the association was lower than the reported among Chinese, a population with a much higher frequency of the risk allele.

DOI: 10.1016/j.cyto.2020.155354
PubMed: 33113474

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000117
to stream Main, to step Curation: 000117

Le document en format XML

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<author><name sortKey="Corte Iglesias, Viviana" sort="Corte Iglesias, Viviana" uniqKey="Corte Iglesias V" first="Viviana" last="Corte-Iglesias">Viviana Corte-Iglesias</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.</title>
<author><name sortKey="G Mez, Juan" sort="G Mez, Juan" uniqKey="G Mez J" first="Juan" last="G Mez">Juan G Mez</name>
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<author><name sortKey="Albaiceta, Guillermo M" sort="Albaiceta, Guillermo M" uniqKey="Albaiceta G" first="Guillermo M" last="Albaiceta">Guillermo M. Albaiceta</name>
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<author><name sortKey="Mel N, Santiago" sort="Mel N, Santiago" uniqKey="Mel N S" first="Santiago" last="Mel N">Santiago Mel N</name>
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<author><name sortKey="Alvarez Arguelles, Marta E" sort="Alvarez Arguelles, Marta E" uniqKey="Alvarez Arguelles M" first="Marta E" last="Alvarez-Argüelles">Marta E. Alvarez-Argüelles</name>
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<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Gil Pe A, Helena" sort="Gil Pe A, Helena" uniqKey="Gil Pe A H" first="Helena" last="Gil-Pe A">Helena Gil-Pe A</name>
<affiliation wicri:level="1"><nlm:affiliation>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vidal Casti Eira, Jose R" sort="Vidal Casti Eira, Jose R" uniqKey="Vidal Casti Eira J" first="José R" last="Vidal-Casti Eira">José R. Vidal-Casti Eira</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Corte Iglesias, Viviana" sort="Corte Iglesias, Viviana" uniqKey="Corte Iglesias V" first="Viviana" last="Corte-Iglesias">Viviana Corte-Iglesias</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saiz, Maria L" sort="Saiz, Maria L" uniqKey="Saiz M" first="María L" last="Saiz">María L. Saiz</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name>
<affiliation wicri:level="1"><nlm:affiliation>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coto, Eliecer" sort="Coto, Eliecer" uniqKey="Coto E" first="Eliecer" last="Coto">Eliecer Coto</name>
<affiliation wicri:level="3"><nlm:affiliation>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain; Universidad de Oviedo, Oviedo, Spain; Red de Investigación Renal (REDINREN), Madrid, Spain. Electronic address: eliecer.coto@sespa.es.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain; Universidad de Oviedo, Oviedo, Spain; Red de Investigación Renal (REDINREN), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cytokine</title>
<idno type="eISSN">1096-0023</idno>
<imprint><date when="2021" type="published">2021</date>
</imprint>
</series>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Asian Continental Ancestry Group (genetics)</term>
<term>COVID-19 (blood)</term>
<term>COVID-19 (epidemiology)</term>
<term>COVID-19 (genetics)</term>
<term>European Continental Ancestry Group (genetics)</term>
<term>Female (MeSH)</term>
<term>Gene Frequency (MeSH)</term>
<term>Genetic Predisposition to Disease (MeSH)</term>
<term>Genotype (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Linear Models (MeSH)</term>
<term>Male (MeSH)</term>
<term>Membrane Proteins (blood)</term>
<term>Membrane Proteins (genetics)</term>
<term>Middle Aged (MeSH)</term>
<term>Polymorphism, Genetic (MeSH)</term>
<term>RNA-Binding Proteins (blood)</term>
<term>RNA-Binding Proteins (genetics)</term>
<term>Risk Factors (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Fréquence d'allèle (MeSH)</term>
<term>Génotype (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Modèles linéaires (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Polymorphisme génétique (MeSH)</term>
<term>Population d'origine asiatique (génétique)</term>
<term>Population d'origine européenne (génétique)</term>
<term>Protéines de liaison à l'ARN (génétique)</term>
<term>Protéines de liaison à l'ARN (sang)</term>
<term>Protéines membranaires (génétique)</term>
<term>Protéines membranaires (sang)</term>
<term>Prédisposition génétique à une maladie (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Membrane Proteins</term>
<term>RNA-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asian Continental Ancestry Group</term>
<term>COVID-19</term>
<term>European Continental Ancestry Group</term>
<term>Membrane Proteins</term>
<term>RNA-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Population d'origine asiatique</term>
<term>Population d'origine européenne</term>
<term>Protéines de liaison à l'ARN</term>
<term>Protéines membranaires</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Protéines de liaison à l'ARN</term>
<term>Protéines membranaires</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Linear Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Genetic</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Modèles linéaires</term>
<term>Mâle</term>
<term>Polymorphisme génétique</term>
<term>Prédisposition génétique à une maladie</term>
<term>Sujet âgé</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND AND AIMS</b>
</p>
<p>The interferon-induced transmembrane proteins play an important antiviral role by preventing viruses from traversing the cellular lipid bilayer. IFITM3 gene variants have been associated with the clinical response to influenza and other viruses. Our aim was to determine whether the IFITM3 rs12252 polymorphism was associated with the risk of developing severe symptoms of COVID-19 in our population.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>A total of 288 COVID-19 patients who required hospitalization (81 in the intensive care unit) and 440 age matched controls were genotyped with a Taqman assay. Linear regression models were used to compare allele and genotype frequencies between the groups, correcting for age and sex.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Carriers of the minor allele frequency (rs12252 C) were significantly more frequent in the patients compared to controls after correcting by age and sex (p = 0.01, OR = 2.02, 95%CI = 1.19-3.42). This genotype was non-significantly more common among patients who required ICU.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>The IFITM3 rs12252 C allele was a risk factor for COVID-19 hospitalization in our Caucasian population. The extent of the association was lower than the reported among Chinese, a population with a much higher frequency of the risk allele.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33113474</PMID>
<DateCompleted><Year>2021</Year>
<Month>01</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>01</Month>
<Day>04</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-0023</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>137</Volume>
<PubDate><Year>2021</Year>
<Month>01</Month>
</PubDate>
</JournalIssue>
<Title>Cytokine</Title>
<ISOAbbreviation>Cytokine</ISOAbbreviation>
</Journal>
<ArticleTitle>The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.</ArticleTitle>
<Pagination><MedlinePgn>155354</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1043-4666(20)30370-7</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cyto.2020.155354</ELocationID>
<Abstract><AbstractText Label="BACKGROUND AND AIMS">The interferon-induced transmembrane proteins play an important antiviral role by preventing viruses from traversing the cellular lipid bilayer. IFITM3 gene variants have been associated with the clinical response to influenza and other viruses. Our aim was to determine whether the IFITM3 rs12252 polymorphism was associated with the risk of developing severe symptoms of COVID-19 in our population.</AbstractText>
<AbstractText Label="METHODS">A total of 288 COVID-19 patients who required hospitalization (81 in the intensive care unit) and 440 age matched controls were genotyped with a Taqman assay. Linear regression models were used to compare allele and genotype frequencies between the groups, correcting for age and sex.</AbstractText>
<AbstractText Label="RESULTS">Carriers of the minor allele frequency (rs12252 C) were significantly more frequent in the patients compared to controls after correcting by age and sex (p = 0.01, OR = 2.02, 95%CI = 1.19-3.42). This genotype was non-significantly more common among patients who required ICU.</AbstractText>
<AbstractText Label="CONCLUSIONS">The IFITM3 rs12252 C allele was a risk factor for COVID-19 hospitalization in our Caucasian population. The extent of the association was lower than the reported among Chinese, a population with a much higher frequency of the risk allele.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gómez</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain; Red de Investigación Renal (REDINREN), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Albaiceta</LastName>
<ForeName>Guillermo M</ForeName>
<Initials>GM</Initials>
<AffiliationInfo><Affiliation>Unidad de Cuidados Intensivos Cardiológicos, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain; Universidad de Oviedo, Oviedo, Spain; CIBER-Enfermedades Respiratorias. Instituto de Salud Carlos III, Madrid, Spain; Instituto Universitario de Oncología del Principado de Asturias. Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cuesta-Llavona</LastName>
<ForeName>Elías</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>García-Clemente</LastName>
<ForeName>Marta</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Neumología, Hospital Universitario Central Asturias, Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>López-Larrea</LastName>
<ForeName>Carlos</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Inmunología, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain; Universidad de Oviedo, Oviedo, Spain; Red de Investigación Renal (REDINREN), Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Amado-Rodríguez</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Unidad de Cuidados Intensivos Cardiológicos, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain; Universidad de Oviedo, Oviedo, Spain; CIBER-Enfermedades Respiratorias. Instituto de Salud Carlos III, Madrid, Spain; Instituto Universitario de Oncología del Principado de Asturias. Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>López-Alonso</LastName>
<ForeName>Inés</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain; CIBER-Enfermedades Respiratorias. Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Melón</LastName>
<ForeName>Santiago</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Microbiología, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alvarez-Argüelles</LastName>
<ForeName>Marta E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Microbiología, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gil-Peña</LastName>
<ForeName>Helena</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vidal-Castiñeira</LastName>
<ForeName>José R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Corte-Iglesias</LastName>
<ForeName>Viviana</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saiz</LastName>
<ForeName>María L</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alvarez</LastName>
<ForeName>Victoria</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Coto</LastName>
<ForeName>Eliecer</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain; Universidad de Oviedo, Oviedo, Spain; Red de Investigación Renal (REDINREN), Madrid, Spain. Electronic address: eliecer.coto@sespa.es.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>10</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Cytokine</MedlineTA>
<NlmUniqueID>9005353</NlmUniqueID>
<ISSNLinking>1043-4666</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C080082">IFITM3 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016601">RNA-Binding Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044466" MajorTopicYN="N">Asian Continental Ancestry Group</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044465" MajorTopicYN="N">European Continental Ancestry Group</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016014" MajorTopicYN="N">Linear Models</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016601" MajorTopicYN="N">RNA-Binding Proteins</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Antiviral protein</Keyword>
<Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">Gene polymorphism</Keyword>
<Keyword MajorTopicYN="Y">Genetic association</Keyword>
<Keyword MajorTopicYN="Y">IFITM3 gene</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>10</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>10</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>10</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>10</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2021</Year>
<Month>1</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>10</Month>
<Day>28</Day>
<Hour>20</Hour>
<Minute>6</Minute>
</PubMedPubDate>
</History>
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<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Communauté de Madrid</li>
</region>
<settlement><li>Madrid</li>
</settlement>
</list>
<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="G Mez, Juan" sort="G Mez, Juan" uniqKey="G Mez J" first="Juan" last="G Mez">Juan G Mez</name>
</region>
<name sortKey="Albaiceta, Guillermo M" sort="Albaiceta, Guillermo M" uniqKey="Albaiceta G" first="Guillermo M" last="Albaiceta">Guillermo M. Albaiceta</name>
<name sortKey="Alvarez Arguelles, Marta E" sort="Alvarez Arguelles, Marta E" uniqKey="Alvarez Arguelles M" first="Marta E" last="Alvarez-Argüelles">Marta E. Alvarez-Argüelles</name>
<name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name>
<name sortKey="Amado Rodriguez, Laura" sort="Amado Rodriguez, Laura" uniqKey="Amado Rodriguez L" first="Laura" last="Amado-Rodríguez">Laura Amado-Rodríguez</name>
<name sortKey="Corte Iglesias, Viviana" sort="Corte Iglesias, Viviana" uniqKey="Corte Iglesias V" first="Viviana" last="Corte-Iglesias">Viviana Corte-Iglesias</name>
<name sortKey="Coto, Eliecer" sort="Coto, Eliecer" uniqKey="Coto E" first="Eliecer" last="Coto">Eliecer Coto</name>
<name sortKey="Cuesta Llavona, Elias" sort="Cuesta Llavona, Elias" uniqKey="Cuesta Llavona E" first="Elías" last="Cuesta-Llavona">Elías Cuesta-Llavona</name>
<name sortKey="Garcia Clemente, Marta" sort="Garcia Clemente, Marta" uniqKey="Garcia Clemente M" first="Marta" last="García-Clemente">Marta García-Clemente</name>
<name sortKey="Gil Pe A, Helena" sort="Gil Pe A, Helena" uniqKey="Gil Pe A H" first="Helena" last="Gil-Pe A">Helena Gil-Pe A</name>
<name sortKey="L Pez Alonso, Ines" sort="L Pez Alonso, Ines" uniqKey="L Pez Alonso I" first="Inés" last="L Pez-Alonso">Inés L Pez-Alonso</name>
<name sortKey="L Pez Larrea, Carlos" sort="L Pez Larrea, Carlos" uniqKey="L Pez Larrea C" first="Carlos" last="L Pez-Larrea">Carlos L Pez-Larrea</name>
<name sortKey="Mel N, Santiago" sort="Mel N, Santiago" uniqKey="Mel N S" first="Santiago" last="Mel N">Santiago Mel N</name>
<name sortKey="Saiz, Maria L" sort="Saiz, Maria L" uniqKey="Saiz M" first="María L" last="Saiz">María L. Saiz</name>
<name sortKey="Vidal Casti Eira, Jose R" sort="Vidal Casti Eira, Jose R" uniqKey="Vidal Casti Eira J" first="José R" last="Vidal-Casti Eira">José R. Vidal-Casti Eira</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidVariantV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000005 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000005 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidVariantV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:33113474
   |texte=   The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:33113474" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidVariantV1

This area was generated with Dilib version V0.6.38.
Data generation: Tue Jan 26 18:10:18 2021. Site generation: Tue Jan 26 18:10:59 2021

	Serveur d'exploration sur les variants du Covid
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les variants du Covid

The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.

The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki